|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We studied the generalizability of the associations with 11 risk variants for CRC on 8q23 (rs16892766), 8q24 (rs6983267), 9p24 (rs719725), 10p14 (rs10795668), 11q23 (rs3802842), 14q22 (rs4444235), 15q13 (rs4779584), 16q22 (rs9929218), 18q21 (rs4939827), 19q13 (rs10411210), and 20p12 (rs961253) in a multiethnic sample of 2,472 CRC cases, 839 adenoma cases and 4,466 controls comprised of European American, African American, Native Hawaiian, Japanese American, and Latino men and women.
|
21071539 |
2011 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers.
|
17618282 |
2007 |
|
rs67085638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified that CCAT1 rs67085638 polymorphism was associated with an increased risk of CRC (OR = 1.72, 95%CI = 1.14-2.58, P = 0.009 in heterozygote codominant model; OR = 1.67, 95%CI = 1.13-2.47, P = 0.010 in dominant model).
|
29666003 |
2018 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found indications that aspirin interacted with rs6983267 close to MYC (encoding a transcription factor involved in cell cycle progression, apoptosis and cellular transformation) and NSAIDs interacted with rs3024505 and rs1800872 in or close to IL10 (encoding IL-10) in preventing CRC.
|
24889212 |
2014 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found no significant differences between the association of rs6983267 and colorectal cancer and colorectal adenomas.
|
21455501 |
2011 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We confirmed that the homozygous T/T allele of rs6983267 c-MYC indicated an interaction between dietary seaweed intake and both overall CRC and rectal cancer (CRC OR [95% CI] = 0.52 [0.34-0.81], P for interaction = 0.015; rectal cancer = 0.45 [0.25-0.79], P for interaction = 0.007, T/T carriers with high total seaweed intake vs. T/T carriers with low total seaweed intake).
|
31300834 |
2019 |
|
rs7837328
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We also replicated the association between CRC and SNPs on 8q24 (rs6983267 and rs7837328, p = 1.51 × 10⁻⁸ and 7.44 × 10⁻⁸, ORs of 1.18 and 1.17, respectively).
|
21242260 |
2011 |
|
rs6983267
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
To validate this finding, we genotyped rs6983267 in three additional CRC case-control series (4,361 affected individuals and 3,752 controls; 1,901 affected individuals and 1,079 controls; 1,072 affected individuals and 415 controls) and replicated the association, providing P = 1.27 x 10(-14) (allelic test) overall, with odds ratios (ORs) of 1.27 (95% confidence interval (c.i.): 1.16-1.39) and 1.47 (95% c.i.
|
17618284 |
2007 |
|
rs6983267
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
To validate this finding, we genotyped rs6983267 in three additional CRC case-control series (4,361 affected individuals and 3,752 controls; 1,901 affected individuals and 1,079 controls; 1,072 affected individuals and 415 controls) and replicated the association, providing P = 1.27 x 10(-14) (allelic test) overall, with odds ratios (ORs) of 1.27 (95% confidence interval (c.i.): 1.16-1.39) and 1.47 (95% c.i.
|
17618284 |
2007 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To validate this finding, we genotyped rs6983267 in three additional CRC case-control series (4,361 affected individuals and 3,752 controls; 1,901 affected individuals and 1,079 controls; 1,072 affected individuals and 415 controls) and replicated the association, providing P = 1.27 x 10(-14) (allelic test) overall, with odds ratios (ORs) of 1.27 (95% confidence interval (c.i.): 1.16-1.39) and 1.47 (95% c.i.
|
17618284 |
2007 |
|
rs7014346
|
|
|
0.830 |
GeneticVariation |
BEFREE |
This study examined the associations among dietary seaweed intake (gim, miyeok, and dashima), single-nucleotide polymorphisms (SNPs; rs6983267, rs7014346, and rs719725), and CRC risk in a Korean population.
|
31300834 |
2019 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the 8q24.21-rs6983267 polymorphism is associated with CRC/CRA susceptibility, but these associations vary in different ethnic populations.
|
24375194 |
2014 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.
|
22434246 |
2012 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The presence of the minor allele of rs6983267 at 8q24.21 worsened the prognosis of CRC through up-regulation of MYC transcription.
|
22976378 |
2013 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The polymorphism rs6983267 showed a significant association with CRC in a Japanese population.
|
19857256 |
2009 |
|
rs1456315
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The genotyping analysis for SNP rs1456315 showed increased association with colorectal cancer with the homozygous CC variant allele (OR: 2.09; χ2 = 4.95; CI: 1.08-4.02; p = 0.02), the minor allele frequency, and additive genotype, respectively (OR: 1.55; χ2 = 6.24; CI: 1.09-2.19; p = 0.01) & (OR: 1.64; χ2 = 4.04; CI: 1.01-2.67; p = 0.04).
|
31487296 |
2019 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The genotypes of rs6983267 in peripheral blood and primary cancers, MYC activity and copy number (CN) alteration were examined in 107 CRCs.
|
24390711 |
2014 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers.
|
27875818 |
2017 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The element drove expression of a reporter gene in a pattern that is consistent with regulation by the key CRC pathway Wnt. rs6983267 affects a binding site for the Wnt-regulated transcription factor TCF4, with the risk allele G showing stronger binding in vitro and in vivo.
|
19561604 |
2009 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs6983267 in region 3, previously implicated in CRC risk, trended toward association with disease in European Americans but not in African Americans.
|
19520795 |
2009 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs6983267 locus is also strongly associated with colorectal cancer.
|
18704501 |
2008 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The CRC SNPs accounted for 4.3% of the variation in multiple adenoma risk, with three SNPs (rs6983267, rs10795668, rs3802842) explaining 3.0% of the variation.
|
24801760 |
2015 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
|
19561607 |
2009 |
|
rs6983267
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Stratified analyses indicated that rs6983267 significantly increased the risk of colorectal cancer in Caucasians, prostate cancer in Caucasians and Asians, thyroid cancer in Caucasians and lung cancer in Asians.
|
28915683 |
2017 |